The Seven Sisters cliffs are occasionally used in filmmaking and television production as a stand-in for the more famous White Cliffs of Dover, since they are relatively free of anachronistic modern development and are also allowed to erode naturally. As a result, the Seven Sisters and Beachy Head remain a bright white colour, whereas the White Cliffs of Dover are protected due to the important port and are therefore increasingly covered in vegetation and are greening as a result.
They have been featured in a number of movies, including at Robin Hood: Prince of Thieves, Atonement where Robbie and Cecilia always wanted to live. Much of the 2015 feature film Mr. Holmes was filmed around the Seven Sisters. The 2019 film Hope Gap, starring Bill Nighy and Annette Bening was against the backdrop of Seaford Head.